Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia
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منابع مشابه
Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia
Necroptosis is a highly pro-inflammatory mode of cell death regulated by RIP (or RIPK)1 and RIP3 kinases and mediated by the effector MLKL. We report that diverse bacterial pathogens that produce a pore-forming toxin (PFT) induce necroptosis of macrophages and this can be blocked for protection against Serratia marcescens hemorrhagic pneumonia. Following challenge with S. marcescens, Staphyloco...
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ژورنال
عنوان ژورنال: PLOS Pathogens
سال: 2015
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1005337